30 Rock Liz: Hey, nerds! Who's got two thumbs, speaks limited French, and hasn't cried once today? [pointing both thumbs at herself] This moi.

Scrubs Dr. Kelso: Hey champ, what has two thumbs and doesn't give a crap? [points to self with thumbs] Bob Kelso. How ya doin'.

The Golden Girls Rose: We wanted to get the best corner before Johnny No-Thumbs shows up with his lunch wagon.
Dorothy: Johnny No-Thumbs ?
Rose: Well actually, he has several fingers missing from each hand. It's remarkable to watch him make a veal and pepper hero. [heads for the door]
Dorothy: Ma, you are trying to muscle in on a guy named Johnny No-Thumbs? Are you crazy? He's probably connected with the mob!
Sophia: Relax! If they were his friends, he'd still have his thumbs! [opens the front door]
Rose: He's a very sweet man, although the first time he waved hello, Sophia misunderstood and gave him the finger back.

Eureka (Taggart is giving Tess a thumbs up)
Zane: What's that?
Taggart: It's her first day, trying to keep her in a positive frame of mind. (Tess thumbs-up back)
Zane: Oh. That's nice of you. Is it working?
Taggart: Yeah, I think so.
Tess: (on other side of glass, cheerfully) We are so screwed.

Mystery Science Theater 3000 [During a campy scene, the "Angels" discuss an attack on an illicit drug facility.]
Michelle: We voted before, we'll vote now. Thumbs up, we attack. Down, we get outta here.
[Terry sticks her thumb up.]
Mike [as Terry]: Hey, look! It evolved last night! It's opposable now!
[Everyone sticks their thumbs out, up.]
Servo [as Maria]: Hah-hah! It's anonymous!

Adam's Rib Amanda, my love, why do you stay married to a legal beagle with ten thumbs?

Macbeth by William Shakespeare By the pricking of my thumbs,
Something wicked this way comes: —
Open, locks,
Whoever knocks!

Fantastic Four Sweet! (referring to Sue and Richard's terms of Supernova) Got it. Supernova. Bad. (thumbs up)

Big Time Rush In the studio: [Kendall and Kelly are staring with their mouths open in shock while listening to Gustavo's song.]
Gustavo: [singing with Buddha Bob] There's a rainbow made of love, floating in the new day sky, candy castle up above, this must be New Town High!
Kendall: [looks at Kelly, shakes his head in disbelief and slaps himself]
Kelly: [presses a button, fake smiling and gives a thumbs up to Gustavo] The producer is coming over tomorrow and he's going to HATE THIS SONG!
Kendall: [fakes smiling and gives Gustavo a thumbs up also] I know.

Johnny the Homicidal Maniac by Jhonen Vasquez Tess: "Okayy!! And, hey, let's also thrust our thumbs deep into our EYE-SOCKETS!! WHEEEE!! C'mon, how stupid are you!?"